Salt, Vinegar, and Glyphosate

I’ve been asked quite a few times over the last several years about a “homemade” herbicide recipe that is floating around the web. Many of you have probably seen it posted to Facebook or Twitter or Pinterest, or on your favorite home gardening site. One of my favorite descriptions calls it a “magical, natural, weed killing potion.” The recipe is largely the same regardless of the source. There are a pretty wide variety of claims about its safety, effectiveness, and “naturalness” depending on the website. One site even says it is “an alternative to chemical weed killers.” [Spoiler: it contains chemicals.]

imageThe recipe is nearly always a subtle modification of:

  • ½ gallon of vinegar
  • ½ cup of salt
  • 2 tablespoons of dish soap

Vinegar contains acetic acid, a chemical (yes, a chemical) with well-known herbicidal properties; it is commonly used by organic gardeners and farmers as a herbicide. The knowledge that salt (sodium chloride, usually) has herbicidal properties goes waaaayyyy back. Soap (even soap is a chemical) is added to increase the spreading of droplets on the weed leaf surface. Most commercial herbicides also contain soaps for this purpose, although we usually refer to them as “surfactants” in that context. The combination of acetic acid, salt, and soap will certainly kill many annual weeds, especially if applied when the weeds are small.

The question I get most often about this homemade mixture is “how does it compare to commercial herbicides?” In particular, how does it compare to Roundup (the trade name for many glyphosate formulations)? This question is especially relevant since several websites tout the mixture as a safe and inexpensive alternative to glyphosate.


Comparing the homemade mixture to glyphosate is difficult, because the situation will often dictate which herbicide is the better choice. If you are trying to kill small, annual weeds, I would expect the homemade solution to be as effective as glyphosate. The vinegar + salt solution will probably burn the weeds down faster than glyphosate, but glyphosate would likely work slightly better over the long term, especially on large weeds. The glyphosate molecule is systemic, that is, it will travel throughout the plant (even down to the roots) to effectively kill all plant parts. The vinegar + salt solution, on the other hand, works on contact primarily by disrupting the integrity of the cell membranes and desiccating the plant. It will not travel long distances through the plant (say, from one leaf to another). So if you don’t get complete coverage of the plant leaves with the vinegar + salt solution, there is potential for the plant to re-grow from the living tissues. Coverage with glyphosate is less crucial, since the herbicide molecule will travel to parts of the plant that were not sprayed.

This difference between systemic and contact herbicides is very important in how to best use each product. Because glyphosate travels through the plant, it can control perennial weeds, such as Canada thistle and quackgrass. The vinegar + salt solution, since it doesn’t move throughout the plant, will not be effective on perennial weeds. It will burn off the top growth of perennials (which may be desirable), but it will not provide long-term control.

The contact nature of the vinegar + salt mixture can be a benefit, though. If you need to kill weeds in close proximity to a desirable plant (say, killing chickweed in a flower bed), then glyphosate can be problematic. Only one or two stray drops from the glyphosate spray bottle onto a flower might be enough to kill the entire plant. A few stray drops of the vinegar + salt solution, on the other hand, will probably cause a little speckling but won’t kill the desirable plants. The exception would be if you continually spray salt in the same area, you can end up with too much salt in the soil, and that will damage nearly all plants. Acetic acid and glyphosate break down rather quickly in the soil, and so won’t cause any long-term soil problems.

So there are certainly some scenarios where the homemade herbicide mixture might be preferable to glyphosate for practical reasons. Comparing effectiveness between the two herbicides is difficult; they both have a potential fit depending on the situation. But what about the “inexpensive” and “safe” claims? I did a little homework to see how the homemade herbicide mixture compares to glyphosate with respect to cost and toxicity.


For costs, I went to Walmart and checked prices for vinegar, salt, and soap.

Walmart prices: Price to make up 1 gallon of spray:
Heinz White Vinegar, 1 gallon = $2.82
Morton Table Salt, 26oz = $0.72
Dawn 24 fl oz = $2.63
1 gallon vinegar = $2.82
1 cup salt (0.6 lbs) = $0.27
4 tablespoons soap (2 fl oz) = $0.22
 Name brands: $3.31/gallon
Great Value vinegar, 1 gallon = $2.38
Great Value salt, 26oz = $0.42
Great value soap, 24 fl oz = $1.97
1 gallon vinegar = $2.38
1 cup salt (0.6 lbs) = $0.16
4 tablespoons soap (2 fl oz) = $0.16
 Walmart brands: $2.70/gallon

It would cost approximately $3.31 to mix up one gallon of homemade herbicide, using prices from Walmart. This is using name-brand products available at most grocery stores; one could lower the price further by buying the Walmart branded products instead of name-brands. If I bought Walmart’s Great Value brands, the price would be reduced to $2.70/gallon.

My local Walmart doesn’t sell a Roundup-branded product that contains only glyphosate; there were always other herbicides included ranging from triclopyr (for woody species and vine control) to diquat (for quick burndown) or iGlyphosate-based herbicidesmazapic (for long-term residual control). But there were several products that contained only glyphosate. A half-gallon of Eliminator Weed & Grass Killer Concentrate was available for $27.97. At first glance, this seems much more expensive than the homemade mixture; however, to mix up 1 gallon of spray solution, you only need to add 1.5 fluid ounces of the concentrated product. At that rate, the cost of the glyphosate solution is only $0.66/gallon. The label states that for “Tough Weed Control” you can mix up to 2.5 fluid ounces per gallon, raising the cost to $1.09/gallon. Even then, glyphosate is actually less expensive than the homemade mixture on a per-gallon, ready-to-spray basis.


For the toxicity comparison, I only looked up the mammalian toxicity values for glyphosate, acetic acid, and salt. Rat acute oral toxicity values and rabbit acute dermal toxicity values for all three chemicals are summarized in the following table. The toxicity values are presented in mg of material per kg of body weight of the test organism. The LD50 is the dose of the chemical that would kill 50% of the test population; in this case rats dosed orally or rabbits dosed on the skin. Low LD50 numbers mean higher toxicity.


acetic acid

salt (sodium chloride)

— mg/kg —

— mg/kg —

— mg/kg —

rat oral LD50




rabbit dermal LD50




In both toxicity measures, acetic acid is more toxic than glyphosate. Salt is more toxic to rats compared to glyphosate when exposed orally. The dermal toxicity numbers are a little more difficult to interpret, since for both glyphosate and salt, the values are listed as greater than a value. This typically means that the experimenters did not kill enough of the test rabbits at the highest doses used in the studies; so we know that glyphosate is safe at least up to 2,000 mg/kg and salt is safe at least up to 10,000 mg/kg. But we can determine from this data that acetic acid is more toxic than both glyphosate or salt. Pound per pound, glyphosate actually appears to be less acutely toxic to the mammalian test organisms compared to acetic acid or salt.

But this is only half the story with respect to toxicity. To estimate the actual risk of these products, we need to know not only the toxicity, but also the use rate; the dose makes the poison. Even highly toxic substances can be used safely if the dose is sufficiently low, and seemingly safe chemicals can be problematic if the dose is too high.

To figure out the actual risk, we need to calculate the amount of the toxic substances being applied. Most distilled white vinegar is 5% acetic acid (50 grain). At this concentration, one gallon of the homemade mixture would contain 6.4 fluid ounces of acetic acid (the active ingredient). One gallon of acetic acid weighs 8.74 lbs; so 6.4 fluid ounces would weigh 0.437 lbs; so there is 0.44 lbs of acetic acid per gallon of homemade mixture. To convert this to similar units as the LD50 values, 0.44 lbs equals 198,220 mg.

Eliminate Grass & Weed Killer contains 3.7 lbs of glyphosate acid per gallon; or 0.0289 lbs glyphosate acid per fluid ounce. At the higher labeled rate of 2.5 fluid ounces of product per gallon, there would be 0.07 lbs of glyphosate acid per gallon of mixed product. Similarly converting this to the same units as the LD50 values, 0.07 lbs equals 31,751.5 mg. So it appears that glyphosate, the less toxic chemical, is being applied at a rate 6-times lower compared to acetic acid.

Let’s do one more calculation to put these toxicity numbers into perspective. Male rats can weigh up to 500 g, or 0.5 kg. One gallon of the homemade mixture contains 198,200 mg of acetic acid, or approximately enough to kill 59 rats, if administered orally. One gallon of mixed glyphosate solution contains 31,752 mg glyphosate, or enough to kill 6 rats. The acetic acid in the homemade mixture is nearly 10 times more lethal than the glyphosate in the Eliminate mixture. And this doesn’t include the salt.

How could this be, you ask? Everything you’ve read on the internet says glyphosate is causing ailments from autism to obesity. How could glyphosate be less toxic than vinegar? Truth is, it is easy to make a chemical (any chemical) sound pretty nasty, even if you use verifiable, factual information. For example, sodium chloride, one of the ingredients in the homemade herbicide solution, is mutagenic for mammalian somatic cells and bacteria. Another ingredient, acetic acid, is highly corrosive, can aggravate respiratory disorders, and even cause permanent vision loss. Does this sound like something you want to be spraying in the same yard where your children and pets play? Should you be dousing your yard with a potent chemical cocktail that causes mutations in humans and causes blindness? And now we learn that this chemical cocktail is nearly 10 times more lethal to mammals than glyphosate, one of the most potent weed killers on the planet! If you’re less scrupulous about your sources, you can even find links between acetic acid and a multitude of disorders, including eczema, psoriasis, shingles, and herpes. You read that right; THIS HOMEMADE HERBICIDE MIXTURE MIGHT GIVE YOU HERPES!

Maybe you’re not worried about the safety aspect; you simply don’t want to purchase Roundup because you dislike Monsanto. Well, don’t forget that vinegar is often made from corn, and most corn in the US has the Roundup Ready trait (which was developed by Monsanto). So the vinegar you are using to spray your weeds is probably made from corn that was sprayed with glyphosate: the very herbicide you were trying to avoid.

What does it all mean?

All joking aside, the important thing to keep in mind is that both the homemade vinegar + salt mixture and Roundup are pretty darn safe when used properly, they’re both relatively inexpensive, and both can provide effective weed control in the appropriate situation. Now, all this discussion has made me hungry for some Roundup Ready sweet corn, with just a little salt, and a salad with a nice vinaigrette dressing.


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  1. Vinegar won’t kill the bees- it is very good for killing off grasses and weeds. Spray, cover for 3-4 weeks, let the sun do its thing. Water well. Pull up the dead weeds & grasses, and you can prepare your soil for planting. For control of beetles- a couple of bantams, indian runner ducks or regular size hens will eat them. They don’t do much damage to the crop. For aphids, water, ammonia and biodegradable dish soap. the soap dissolves the outer shell, the ammonia draws out the insect’s moisture, and it dies. For fungus, remove sick leaves as soon as you see it, and spray with dish soap and water. Keep the plant dry for at least 24 hours, water the root only. Snails and slugs, collect and drown in salt water as many as you can find. Put tins containing beer and water into the ground, smooth the soil around the top. they will be drawn to the beer, fall in, and drown. Raised beds, put 2 strands of thin wire just far enough apart for a small snail’s body to touch both. Attach to a battery, put battery in a lunch box with the requisite holes made, make the holes watertight. Snails and slugs won’t come past the electrified wire. Does it work? Does for me. The bit of my own garden crop I sell, I have people waiting in line for- no synthesised chemicals, no pesticide, no herbicide.

    1. Who says it is not harmful to bees? Heinz company? Where is Heinz’ research that proves that bees wont be harmed? Seems suspicious to me that a corporation that would benefit from people using its product to kill weeds doesn’t feel it has a responsibility to prove its product dont kill bees. What is it trying to hide? If I spray a patch of weeds where bees might happen to be foraging, the bees won’t be affected by a caustic product like vinegar? I’d be interested in any study that confined bees in a cage with vinegar — did they thrive. Hell, I might try the experiment myself this spring. Can’t wait to see the bees just live happily on. What happens if you expose human cells to vinegar in a petri dish-are the cells ok? There are certain types of cells that die when exposed to distilled water. So vinegar wouldn’t even harm them? wow. Sure, its easy to say the homemade product is risk free when no one is looking for adverse effects. Its like having a referee only looking for penalties commited by one team.

      Look, I agree that the homemade concoction probably is not threatening to bee population health when used sparingly at garden scale levels. . But I am not so sure if it were applied regularly at any commercial scale, that bee welfare would be unaffected, and I am not very convinced that frequent use of a caustic acid, salt and soap product wouldn’t affect soil health and microrganism life. I also suspect that glysophate used in the manner you described would have no more adverse impact than the homemade recipe.

  2. This was a very useful article, and opened my eyes up to a few facts that I was not aware of. However, you’re going to need to prove to me that vinegar causes herpes. I became infected with herpes due to the sexual abuse and torture I survived as a child. Furthermore, no one I know that has any form of herpes claims that it was due to vinegar exposure. Hence my skepticism is understandable. Where is the research on this claim? Thank you.

    1. They should have worded it differently. We both know that the vinegar solution can’t cause herpes or shingles, both are caused by virus, but shingles is caused by a relative, herpes zolster the chicken pox virus. The vinegar’s toxicity can cause an outbreak of any herpes virus already present.

  3. Why. oh, why do you only consider acute toxicity ( LD 50) rather than chronic toxicity?
    The number of studies showing glyphosate toxicity is large and growing. There are a slew of studies examining effects of glyphosate as an endocrine disruptor with the most recent showing it is active at parts / trillion (in environmentally relevant concentrations) at stimulating proliferation of hormone sensitive breast cancer…which vinegar, soap and salt certainly do not. Glyphosate also uncouples oxidative phosphorylation (in our energy factories- mitochondria) and its toxicity is potentiated by adjuvants- not analyzed in toxicity studies.

    No, Monsanto isn’t as safe as vinegar, salt and soap- no matter how much Monsanto and its enabling farmers abusing glyphosate would love to live in denial.

    1. The scientific paper actually says that PURE glyposate causes mutations in isolated tissue cell cultures. Since nobody inhects glyposate into their breasts the results are meaningless.

      The metabolic pathways affected by glyphosate are only found in plants and bacteria, Animals (including insects) are not affected.

      1. The metabolic pathways affected by glyphosate are also found in the beneficial bacteria in your gut. What do you think the knock on effects of that are? It also affects the bacteria in the soil – again , knock on effects?

  4. IF you were to complete a large area say 3 hectars with the Vinager + salt solution. what is the rate you would apply it to the area being sprayed? and is water added to the mixture as well?


    1. Considering how vinegar is made, what would be the cost in potential food crops required to produce enough vinegar to treat say 100 acres. I don’t doubt that the salt, vinegar & soap concoction might actually be practical in certain situations, but is it really a practical option as a substitute for Roundup or any synthetic pesticide on any commercial scale. Is its appeal mostly as a symbolic poke in the eye of Monsanto?

    1. It’s uncool to call people a shill. We need your ideas not ad hominem attacks. We can call each other shills until the cows come home. Let’s do better than that.

      1. How intellectually lazy. Guess when you have no ability to address the merits of an argument, you have no other choice but to fall back on unsubstantiated conspiratoral fantasy, the last resort of the ignorant.

    2. Reminds me of the Johnson line… patriotism being the last refuge of the scoundrel. But this line needs updating.

  5. Hi, like to know for the home made mixture, how often do we need to spray, to prevent damage to crop, and if I am to spray the solution on the crops, what damage will it cause and is the damage reversible? Thank you.

  6. I have a large greenhouse operation and require to kill the weeds outside the houses to prevent airborne seeds and rhizomes from invading the inside of the houses. I see the recipes suggested but I am talking acres of weed control. What concentrations would I have to use to kill the weeds for this size of operation.? Not that I want to use round up but I know that the alternative to control this size of operation would keep me spraying vinegar and soap and salt over and over and over again all summer long.
    Any suggestions on what I would have to do to do a control this size??

  7. Thank you for this article. One of the better ones I have seen on this topic. I have one question; when we are looking at toxicity, it seems there are two considerations — immediate impact (within some kind of short term framework) and then how fast any residual in the soil or the plant matter breaks down (if they do) into inert or harmless forms. If the article discussed this, I missed it. If either one does not break down, and are in contact or consumed by humans, what are the long term risks of accumulation and toxicity of the two herbicide formulas?

    1. The article mentions that vinegar and glyphosate break down readily. The salt however can build up and cause problems.

  8. The vinegar has to be 10 – 20% acidity. Most grocery stores only sell 5%. Garden Centers/nurseries that sell organic and natural products will carry the higher acidity vinegar.

  9. Obviously you work for the weed killer manufacturer. I literally eat and drink vinegar EVERY DAY FOR HEALTH, also there is more salt in the average persons diet than we are talking about using in the home made version. Now dish soap, I would substitute it with plain old washing soda.

  10. I hav 2 tbps vinegar+1 tbps salt+ 2 tbps cleaning solution ,all mixed up,wil it able to cause any harm if drink by self for suicide

  11. Vinegar won’t give you kidney cancer or your kids autism. Is this somekind of shill article? Does anyone believe this BS?

  12. Did I miss it? I don’t seem to find any instructions for using the combination of salt, vinegar and baking soda as a powerful carpet strain remover as the previous page indicated.

  13. I thought it was a fun read… i will try it…. i hope that you are correct and that it does the job? if not i’ll be having a lot of salt and vinegar on my chips (fries) he he he.

  14. Written by an assoc proff who writes for CBI, owned by Monsanto, Dow and other of the big six chemical companies.

  15. Pingback: Quora

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